The Effects of Probiotics on the Treatment of Helicobacter pylori Eradication

ABSTRACT

The standard therapy for Helicobacter pylori eradication consists of double antibiotics and proton pumb inhibitors. In recent years, due to bacterial resistance and adverse events of therapy, the percentage of eradication failure is rising. Several studies have showed that the role of probiotics in the treatment of H. pylori infection as a complement to antibiotics or potential supplement to reduce adverse effects. In animal studies, probiotics such as Lactobacilus inhibited H. pylori induced gastric inflammation. The results of randomized, double-blind, placebo-controlled studies suggest that specific probiotic strains, such as Sacchromyces boulardii and Lactobacillus johnsonni may reduce H. pylori load in the stomach and be helpful increasing eradication rates. Furthermore, probiotic supplmentation can reduce adverse effects induced by antiboitics treatment, and have beneficial effects H. pylori infected individuals.