The antiplaque and bleeding control effects of a cetylpyridinium chloride and tranexamic acid mouth rinse in patients with gingivitis
Journal of Periodontal & Implant Science
;
: 134-142, 2017.
Article
in English
| WPRIM
| ID: wpr-222867
ABSTRACT
PURPOSE:
This study aimed to evaluate the effects of a cetylpyridinium chloride (CPC) and tranexamic acid (TXA) mouth rinse on patients with gingivitis.METHODS:
This randomized, placebo-controlled, double-blind, parallel-group, clinical trial included 45 healthy adults with gingivitis, who were randomized into 2 groups. The experimental group used a 0.05% CPC and 0.05% TXA mouth rinse, and the control group used a placebo mouth rinse. The following clinical indices were assessed at baseline, at 3 weeks, and at 6 weeks the Turesky-Quigley-Hein plaque index (QHI), the Löe-Silness gingival index (GI), and bleeding on marginal probing (BOMP). The subjects used the mouth rinse during the experimental period for 20 seconds, 4–5 times daily (10 mL each time).RESULTS:
There were no significant differences in the clinical indices between the groups at baseline. In the experimental group (CPC+TXA), a statistically significant improvement was evident in the QHI, GI, and BOMP at 3 and 6 weeks. These results were similar to those observed in the control group at 3 and 6 weeks, although the change in BOMP was not statistically significant in that group. At 6 weeks, the experimental group had a significantly lower mean score for the QHI than the control group.CONCLUSIONS:
This study demonstrated that a CPC and TXA mouth rinse exhibited significant antiplaque and anti-gingivitis efficacy, and had a positive effect on bleeding control when used daily for 6 weeks.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tranexamic Acid
/
Cetylpyridinium
/
Periodontal Index
/
Dental Plaque Index
/
Gingivitis
/
Hemorrhage
/
Mouth
Type of study:
Controlled clinical trial
Limits:
Adult
/
Humans
Language:
English
Journal:
Journal of Periodontal & Implant Science
Year:
2017
Type:
Article
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