Tuberculin Skin Test and QuantiFERON-TB Gold Assay before and after Treatment for Latent Tuberculosis Infection among Health Care Workers in Local Tertiary Hospital / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 270-275, 2007.
Article
in Korean
| WPRIM
| ID: wpr-22288
ABSTRACT
BACKGROUND:
The QuantiFERON-TB Gold assay and tuberculin skin test (TST) have been useful test for diagnosing latent tuberculosis infections (LTBI). However, there are few reports on the efficacy of the QuantiFERON-TB Gold assay and TST in evaluating the response after the treatment of LTBI. This study examined the changes in the TST and QuantiFERON-TB Gold assay before and after a treatment for latent tuberculosis in health care workers (HCWs) at a local tertiary hospital.METHODS:
A cohort of volunteers working as nurses and doctors who underwent a TST and QuantiFERON-TB Gold assay was established. The volunteers positive for the QuantiFERON-TB Gold assay had been treated with 3 months of isoniazid (INH) and rifampin (RFP). After completing treatment, the TST and QuantiFERON-TB Gold assay were repeated.RESULTS:
Of the 48 participants (14 doctors, 34 nurses, M F=1137, mean age=29.9+/-5.5 years, mean employment period=74.9+/-64.3 months), 19 (39.6%) tested positive to the TST (mean induration=19.1+/-9.7 mm) and 8 (16.7%) were QuantiFERON-TB Gold assay. Among them, one had active pulmonary tuberculosis. Seven volunteers were consistently positive to both the TST and QuantiFERON-TB Gold assay after being medicated with INH and RFP for 3 months.CONCLUSION:
TST and QuantiFERON-TB Gold assay are unsuitable for evaluating the treatment response of LTBI because they were consistently positive both before and after the anti-tuberculosis medication.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rifampin
/
Skin
/
Tuberculin
/
Tuberculosis, Pulmonary
/
Volunteers
/
Skin Tests
/
Cohort Studies
/
Delivery of Health Care
/
Employment
/
Latent Tuberculosis
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Risk factors
Language:
Korean
Journal:
Tuberculosis and Respiratory Diseases
Year:
2007
Type:
Article
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