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Isolated adrenocorticotropic hormone deficiency associated with empty sella syndrome / 대한내과학회지
Korean Journal of Medicine ; : 597-601, 2008.
Article in Korean | WPRIM | ID: wpr-222962
ABSTRACT
Isolated adrenocorticotropic hormone (ACTH) deficiency is an uncommon disorder for which the pathogenetic mechanism has not yet been identified. It has been reported that isolated ACTH deficiency (ICD) may be accompanied by deficiencies in other pituitary hormones; impaired growth hormone (GH) secretion was noted in 20 to 30% of ICD patients. Here, we describe a female patient with isolated ACTH deficiency accompanied by empty sella syndrome presenting as hypoglycemia, which was confirmed via various endocrine tests and magnetic resonance imaging (MRI) of the sella turcica. The patient's symptoms improved rapidly with prednisolone therapy and, during follow-up, her previously impaired GH response to provocative stimuli and high TSH levels were corrected by glucocorticoid replacement alone. However, treatment failed to normalize plasma IGF-1 levels, suggesting that physiological cortisol levels are necessary for a normal plasma GH response to provocative stimuli.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plasma / Sella Turcica / Insulin-Like Growth Factor I / Hydrocortisone / Prednisolone / Growth Hormone / Magnetic Resonance Imaging / Follow-Up Studies / Adrenal Insufficiency / Adrenocorticotropic Hormone Type of study: Observational study / Prognostic study Limits: Female / Humans Language: Korean Journal: Korean Journal of Medicine Year: 2008 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plasma / Sella Turcica / Insulin-Like Growth Factor I / Hydrocortisone / Prednisolone / Growth Hormone / Magnetic Resonance Imaging / Follow-Up Studies / Adrenal Insufficiency / Adrenocorticotropic Hormone Type of study: Observational study / Prognostic study Limits: Female / Humans Language: Korean Journal: Korean Journal of Medicine Year: 2008 Type: Article