Neuronal Hyperexcitability Mediates Below-Level Central Neuropathic Pain after Spinal Cord Injury in Rats / 한국실험동물학회지
Laboratory Animal Research
;
: 225-232, 2010.
Article
in Korean
| WPRIM
| ID: wpr-223292
ABSTRACT
Spinal cord injury often leads to central neuropathic pain syndromes, such as allodynic and hyperalgesic behaviors. Electrophysiologically, spinal dorsal horn neurons show enhanced activity to non-noxious and noxious stimuli as well as increased spontaneous activity following spinal cord injury, which often called hyperexcitability or central sensitization. Under hyperexcitable states, spinal neurons lose their ability of discrimination and encoding somatosensory information followed by abnormal somatosensory recognition to non-noxious and noxious stimuli. In the present review, we summarize a variety of pathophysiological mechanisms of neuronal hyperexcitability for treating or preventing central neuropathic pain syndrome following spinal cord injury.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spinal Cord
/
Spinal Cord Injuries
/
Posterior Horn Cells
/
Discrimination, Psychological
/
Central Nervous System Sensitization
/
Neuralgia
/
Neurons
Limits:
Animals
Language:
Korean
Journal:
Laboratory Animal Research
Year:
2010
Type:
Article
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