The Experience and Management of Two Cases of Metformin-associated Lactic Acidosis
Journal of the Korean Society of Emergency Medicine
;
: 771-774, 2014.
Article
in English
| WPRIM
| ID: wpr-223350
ABSTRACT
Metformin, a dimethylbiguanide, is an oral antihyperglycemic drug used in treatment of type 2 diabetes mellitus. It has been reported that metformin may be associated with lactic acidosis in patients with clinical conditions such as renal failure and heart failure. Metformin-associated lactic acidosis (MALA) is a rare, but serious complication with a mortality rate of approximately 30~50%. Therefore, an aggressive treatment strategy including hemodialysis is recommended for these patients. Although continuous renal replacement therapy (CRRT) has been administered in hemodynamically unstable patients with MALA, there are few case reports describing the use of CRRT as a therapeutic modality in Korea. Here, we describe the case histories of two MALA patients who underwent treatment with CRRT.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Acidosis
/
Acidosis, Lactic
/
Mortality
/
Renal Dialysis
/
Renal Replacement Therapy
/
Diabetes Mellitus, Type 2
/
Renal Insufficiency
/
Heart Failure
/
Korea
/
Metformin
Type of study:
Prognostic study
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of the Korean Society of Emergency Medicine
Year:
2014
Type:
Article
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