Influences of the Apolipoprotein E Polymorphism on the Development of Coronary Artery Disease and on Serum Lipids in the Korean Males
Korean Circulation Journal
;
: 279-286, 1997.
Article
in Korean
| WPRIM
| ID: wpr-223375
ABSTRACT
BACKGROUND:
Apo E lipoprotein is polymorphic and exists in three common isoforms (E2, E3 and E4), which are the gene products of three apo E alleles, e2, e3 and e4. Apo E lipoprotein plays an important role in the regulation of the lipid metabolism through its ability to bind to receptors. Depending on the genotypes apo E polymorphism is either protective or increases risk for atherosclerosis and coronary artery disease. The purpose of this study is to evaluate 1) the association between apo E allele and the development of coronary artery disease, 2) the association between apo E alleles and dyslipidemia in Korean males.METHODS:
We studied 241 patients with angiographically verified coronary artery disease and 257 male subjects without evidence of coronary artery disease. Apo E genotyping was determined with the INNO-LiPA Apo E kit (Innogenetics, Belgium), which is based on reverse hybridization.RESULTS:
There was a higher frequency of the apo e4 allele in subjects with coronary artery disease than in normal controls. The frequencies of apo E genotype were not significantly associated with apo e2 were associated with higher levels of triglyceride and lower LDL, and the subjects with apo e4 had lower levels of HDL cholesterol.CONCLUSION:
ApoE polymorphism is a genetic marker for risk of the development of coronary artery disease and an important determinant of dyslipidemia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Apolipoproteins
/
Apolipoproteins E
/
Triglycerides
/
Coronary Artery Disease
/
Genetic Markers
/
Coronary Vessels
/
Protein Isoforms
/
Alleles
/
Atherosclerosis
/
Dyslipidemias
Limits:
Humans
/
Male
Language:
Korean
Journal:
Korean Circulation Journal
Year:
1997
Type:
Article
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