Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma
Korean Journal of Pathology
;
: 252-257, 2013.
Article
in English
| WPRIM
| ID: wpr-22351
ABSTRACT
BACKGROUND:
The aim of this study was to determine the cytologic features of anaplastic lymphoma kinase (ALK) expressing pulmonary adenocarcinoma.METHODS:
We analyzed the cytopathological findings of 15 cases of endobronchial ultrasound guided aspiration and a case of bronchial washing. These cases were selected based on the histomorphology of ALK-rearranged lung adenocarcinoma.RESULTS:
Cytology showed mucinous (81.3%) and hemorrhagic (50%) backgrounds. The cells were arranged in tubulopapillary or tubulocribriform patterns (93.8%), and clusters (56.3%) admixed with signet ring cell features (87.5%). The tumor cells were monotonous and uniform with vesicular nuclei and a small nucleolus.CONCLUSIONS:
The characteristic findings were sheets showing a tubulopapillary or tubulocribriform appearance, with vesicular nuclei and a bland chromatin pattern (p<0.001). Scattered signet ring cells were helpful in suggesting ALK-positive adenocarcinoma (p<0.001).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phosphotransferases
/
Chromatin
/
Adenocarcinoma
/
Receptor Protein-Tyrosine Kinases
/
Carcinoma, Non-Small-Cell Lung
/
Lung
/
Lymphoma
/
Mucins
Language:
English
Journal:
Korean Journal of Pathology
Year:
2013
Type:
Article
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