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Marked Individual Variation in Isoflavone Metabolism After a Soy Challenge Can Modulate the Skeletal Effect of Isoflavones in Premenopausal Women
Journal of Korean Medical Science ; : 867-873, 2009.
Article in English | WPRIM | ID: wpr-223645
ABSTRACT
Soy-isoflavones may act as estrogenic agonists or antagonists depending on the endogenous hormone status. These clinical effects can be exerted variably in individuals by the metabolic ability to produce a more potent metabolite than precursors. The objective of this randomized, double-blind, placebo-controlled study was to investigate the skeletal effect of isoflavones according to their metabolic variability in premenopausal women. Volunteers were randomly assigned to receive either soy-extract isoflavones (n=32) or lactose (n=21) once a day for three menstrual cycles. After intervention, the urinary excretions of isoflavones and their metabolites were significantly higher in the soy group than in the placebo group and showed a large inter-individual variation. Women in the soy group were divided into subgroups according to their ability to excrete more potent metabolites. Serum osteocalcin and urine deoxypyridinoline showed a tendency to increase after a challenge in equol high-excretors. Serum osteocalcin concentration in the genistein high-excretors increased significantly after a challenge (P=0.04) but did not increase in either the placebo or genistein low-excretors. An estrogenic antagonistic effect of isoflavones on bone turnover was observed in premenopausal women who are able to produce more potent metabolites.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Bone and Bones / Osteocalcin / Double-Blind Method / Premenopause / Estrogen Antagonists / Amino Acids / Isoflavones Type of study: Controlled clinical trial Limits: Adult / Female / Humans Language: English Journal: Journal of Korean Medical Science Year: 2009 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Bone and Bones / Osteocalcin / Double-Blind Method / Premenopause / Estrogen Antagonists / Amino Acids / Isoflavones Type of study: Controlled clinical trial Limits: Adult / Female / Humans Language: English Journal: Journal of Korean Medical Science Year: 2009 Type: Article