B Cells Promote Th1- Skewed NKT Cell Response by CD1d-TCR Interaction
Immune Network
;
: 218-221, 2013.
Article
in English
| WPRIM
| ID: wpr-223720
ABSTRACT
CD1d expressing dendritic cells (DCs) are good glyco-lipid antigen presenting cells for NKT cells. However, resting B cells are very weak stimulators for NKT cells. Although alpha-galactosylceramide (alpha-GalCer) loaded B cells can activate NKT cells, it is not well defined whether B cells interfere NKT cell stimulating activity of DCs. Unexpectedly, we found in this study that B cells can promote Th1-skewed NKT cell response, which means a increased level of IFN-gamma by NKT cells, concomitant with a decreased level of IL-4, in the circumstance of co-culture of DCs and B Cells. Remarkably, the response promoted by B cells was dependent on CD1d expression of B cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Dendritic Cells
/
B-Lymphocytes
/
Interleukin-4
/
Coculture Techniques
/
Natural Killer T-Cells
/
Galactosylceramides
/
Antigen-Presenting Cells
Language:
English
Journal:
Immune Network
Year:
2013
Type:
Article
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