Emerging Co-signaling Networks in T Cell Immune Regulation
Immune Network
;
: 184-193, 2013.
Article
in English
| WPRIM
| ID: wpr-223725
ABSTRACT
Co-signaling molecules are surface glycoproteins that positively or negatively regulate the T cell response to antigen. Co-signaling ligands and receptors crosstalk between the surfaces of antigen-presenting cells (APCs) and T cells, and modulate the ultimate magnitude and quality of T cell receptor (TCR) signaling. In the past 10 years, the field of co-signaling research has been advanced by the understanding of underlying mechanisms of the immune modulation led by newly identified co-signaling molecules and the successful preclinical and clinical trials targeting co-inhibitory molecules called immune checkpoints in the treatment of autoimmune diseases and cancers. In this review, we briefly describe the characteristics of well-known B7 co-signaling family members regarding the expression, functions and therapeutic implications and to introduce newly identified B7 members such as B7-H5, B7-H6, and B7-H7.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autoimmune Diseases
/
Membrane Glycoproteins
/
Receptors, Antigen, T-Cell
/
T-Lymphocytes
/
Ligands
/
Antigen-Presenting Cells
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Immune Network
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS