ANCA-related crescentic glomerulonephritis in a patient with systemic sclerosis / 대한내과학회지
Korean Journal of Medicine
;
: S154-S157, 2009.
Article
in Korean
| WPRIM
| ID: wpr-223776
ABSTRACT
The renal manifestations of systemic sclerosis include proteinuria, hypertension, azotemia, and renal crisis. Two types of scleroderma renal crisis (SRC) are recognized. Typical SRC is a syndrome consisting of acute-onset malignant hypertension accompanied by rapidly progressive renal failure, hypertensive retinopathy, and elevated plasma renin activity. The other type is normotensive renal failure, which is generally accompanied by antineutrophil cytoplasmic autoantibody (ANCA)-positive crescentic glomerulonephritis. A 51-year-old woman with scleroderma without marked dermatological change developed ANCA-related renal failure. She had neither malignant hypertension nor an elevated plasma rennin concentration. Renal biopsy showed crescentic glomerulonephritis (pauci-immune type), and the myeloperoxidase-specific ANCA (MPO-ANCA) titer was elevated at 1015 AAU. She was cured using steroid pulse therapy, combined with an angiotensin-converting-enzyme inhibitor and angiotensin-II receptor blocker
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Proteinuria
/
Scleroderma, Systemic
/
Biopsy
/
Chymosin
/
Renin
/
Antibodies, Antineutrophil Cytoplasmic
/
Cytoplasm
/
Renal Insufficiency
/
Azotemia
Limits:
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2009
Type:
Article
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