The Analysis of Treatment of Aggressive Fibromatosis Using Oral Methotrexate Chemotherapy
Clinics in Orthopedic Surgery
; : 439-442, 2014.
Article
in En
| WPRIM
| ID: wpr-223880
Responsible library:
WPRO
ABSTRACT
BACKGROUND: Aggressive fibromatosis is a rare but invasive tumor infiltrating widely between fascia and muscle fibers. It has a high tendency to be locally recurrent despite complete resection. Effectiveness of adjuvant treatment for aggressive fibromatosis including radiotherapy, pharmacological agents, hormonal treatments, and chemotherapy have been previously reported. The purpose of this article was to collect and analyze all information regarding the effectiveness and side effects of oral methotrexate in aggressive fibromatosis. METHODS: From 2005 to 2011, eleven patients with aggressive fibromatosis treated with oral methotrexate at our institution were analyzed in this study. Oral methotrexate was administered once per week at 10 mg per week. Authors collected information about effectiveness concerning cases of local recurrence and metastasis. RESULTS: Eleven patients had remission, two patients had local recurrence. Fatal complications or toxicity were not observed. CONCLUSIONS: Oral methotrexate given at this dose and schedule was considered as a useful treatment in primary inoperable fibromatosis and recurrent fibromatosis.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Methotrexate
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Administration, Oral
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Retrospective Studies
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Fibromatosis, Aggressive
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Neoplasm Recurrence, Local
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Antimetabolites, Antineoplastic
Type of study:
Observational_studies
Limits:
Adolescent
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Adult
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Aged
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Child
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Female
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Humans
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Male
Language:
En
Journal:
Clinics in Orthopedic Surgery
Year:
2014
Type:
Article