Phagocytosis and Endocytosis of Silver Nanoparticles Induce Interleukin-8 Production in Human Macrophages
Yonsei Medical Journal
;
: 654-657, 2012.
Article
in English
| WPRIM
| ID: wpr-22414
ABSTRACT
Phagocytosis or endocytosis by macrophages is critical to the uptake of fine particles, including nanoparticles, in order to initiate toxic effects in cells. Here, our data enhance the understanding of the process of internalization of silver nanoparticles by macrophages. When macrophages were pre-treated with inhibitors to phagocytosis, caveolin-mediated endocytosis, or clathrin-mediated endocytosis, prior to exposure to silver nanoparticles, Interleukin-8 (IL-8) production was inhibited. Although cell death was not reduced, the inflammatory response by macrophages was compromised by phagocytosis and endocytosis inhibitors.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phagocytosis
/
Silver
/
Cell Line
/
Cell Survival
/
Interleukin-8
/
Endocytosis
/
Metal Nanoparticles
/
Macrophages
Limits:
Humans
Language:
English
Journal:
Yonsei Medical Journal
Year:
2012
Type:
Article
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