Fatty liver associated with metabolic derangement in patients with chronic kidney disease: A controlled attenuation parameter study
Kidney Research and Clinical Practice
;
: 48-57, 2017.
Article
in English
| WPRIM
| ID: wpr-224474
ABSTRACT
BACKGROUND:
Hepatic steatosis measured with controlled attenuation parameter (CAP) using transient elastography predicts metabolic syndrome in the general population. We investigated whether CAP predicted metabolic syndrome in chronic kidney disease patients.METHODS:
CAP was measured with transient elastography in 465 predialysis chronic kidney disease patients (mean age, 57.5 years).RESULTS:
The median CAP value was 239 (202–274) dB/m. In 195 (41.9%) patients with metabolic syndrome, diabetes mellitus was more prevalent (105 [53.8%] vs. 71 [26.3%], P < 0.001), with significantly increased urine albumin-to-creatinine ratio (184 [38–706] vs. 56 [16–408] mg/g Cr, P = 0.003), high sensitivity C-reactive protein levels (5.4 [1.4–28.2] vs. 1.7 [0.6–9.9] mg/L, P < 0.001), and CAP (248 [210–302] vs. 226 [196–259] dB/m, P < 0.001). In multiple linear regression analysis, CAP was independently related to body mass index (β = 0.742, P < 0.001), triglyceride levels (β = 2.034, P < 0.001), estimated glomerular filtration rate (β = 0.316, P = 0.001), serum albumin (β = 1.386, P < 0.001), alanine aminotransferase (β = 0.064, P = 0.029), and total bilirubin (β = −0.881, P = 0.009). In multiple logistic regression analysis, increased CAP was independently associated with increased metabolic syndrome risk (per 10 dB/m increase; odds ratio, 1.093; 95% confidence interval, 1.009–1.183; P = 0.029) even after adjusting for multiple confounding factors.CONCLUSION:
Increased CAP measured with transient elastography significantly correlated with and could predict increased metabolic syndrome risk in chronic kidney disease patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Triglycerides
/
Bilirubin
/
C-Reactive Protein
/
Serum Albumin
/
Body Mass Index
/
Linear Models
/
Logistic Models
/
Odds Ratio
/
Diabetes Mellitus
/
Alanine Transaminase
Type of study:
Diagnostic study
/
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Kidney Research and Clinical Practice
Year:
2017
Type:
Article
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