Relation of Anti- to Pro-Inflammatory Cytokine Ratios with Acute Myocardial Infarction
The Korean Journal of Internal Medicine
;
: 44-50, 2010.
Article
in English
| WPRIM
| ID: wpr-224532
ABSTRACT
BACKGROUND/AIMS:
Acute myocardial infarction (AMI) is a leading cause of death. Inflammatory processes play an important role in atherosclerosis, which is intimately related to AMI. The aim of this study was to investigate the association between anti-inflammatory and pro-inflammatory cytokines ratios and AMI.METHODS:
A total of 90 AMI patients and 90 age-and sex-matched controls were recruited in this study. Plasma cytokines and conventional risk factors were determined by standard methods.RESULTS:
Patients with AMI showed increased interleukin (IL)-6 and tumor necrosis factor-alpha levels and lower anti- to pro-inflammatory cytokine ratios as compared with controls. A multivariate logistic regression analysis revealed that IL-10 to IL-6 ratio was independently associated with the occurrence of AMI (odds ratio [OR], 5.39; 95% confidence interval [CI], 2.39 to 12.17; p < 0.0001). In contrast, IL-6 levels were no longer significant in the multivariate model (OR, 1.02; 95% CI, 0.932 to 1.12; p = 0.603). A receiver operating characteristic (ROC) curve analysis indicated that IL-6 levels and IL-10 to IL-6 ratios were a significant predictor of AMI (area under ROC curve, 0.892 and 0.851, respectively).CONCLUSIONS:
Our results suggest that the ratio of IL-10 to IL-6 is independently associated with AMI, and reduced levels of this ratio may favor the development of AMI.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Logistic Models
/
Multivariate Analysis
/
Predictive Value of Tests
/
Risk Factors
/
ROC Curve
/
Interleukin-6
/
Interleukin-10
/
Atherosclerosis
/
Myocardial Infarction
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2010
Type:
Article
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