A case of myeloid neoplasm with the PDGFRB rearrangement and eosinophilia / 대한내과학회지
Korean Journal of Medicine
;
: 386-390, 2010.
Article
in Korean
| WPRIM
| ID: wpr-224540
ABSTRACT
Myeloid neoplasm with the platelet-derived growth factor receptor beta (PDGFRB) rearrangement is a myeloproliferative neoplasm. Patients with this disease often have prominent eosinophilia or monocytosis and the presence of t(5;12)(q31~33;p12) or a variant translocation with expression of an ETV6-PDGFRB fusion gene or the PDGFRB rearrangement. We report an 82-year-old woman with a myeloid neoplasm, with the PDGFRB rearrangement, who presented with a dry cough, eosinophilia and thrombocytosis. The chromosome study of the bone marrow showed 46,XX,ins(1;5)(q22;q33q13.3), and fluorescence in situ hybridization (FISH) analysis revealed rearrangement of the PDGFRB gene. The patient was successfully treated with low-dose imatinib.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Piperazines
/
Pyrimidines
/
Thrombocytosis
/
Benzamides
/
Bone Marrow
/
Receptors, Platelet-Derived Growth Factor
/
In Situ Hybridization
/
Cough
/
Receptor, Platelet-Derived Growth Factor beta
/
Eosinophilia
Limits:
Aged
/
Aged80
/
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2010
Type:
Article
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