Prevalence and Clinical Significance of Autoantibodies in Patients with Chronic Hepatitis C / 대한간학회지
The Korean Journal of Hepatology
;
: 200-207, 1999.
Article
in Korean
| WPRIM
| ID: wpr-224747
ABSTRACT
BACKGROUND/AIMS:
Chronic hepatitis C virus (HCV) infection is often associated with extrahepatic autoimmune disease, and autoantibodies such as anti-nuclear antibody (ANA) or anti-smooth muscle antibody (ASA). The presence of autoantibodies may make discrimination between chronic hepatitis C with autoimmune features and type 1 autoimmune hepatitis difficult. We studied the prevalence of autoantibodies in patients with chronic HCV infection and their clinical significance. MATERIALS ANDMETHODS:
ANA, ASA, anti-mitochondrial antibody (AMA), anti-microsomal antibody (AmA), rheumatoid factor (RF), anti-cardiolipin antibody (aCL) and lupus anti-coagulant (LA) were tested in 116 patients (80 chronic hepatitis C, 36 liver cirrhosis). Genotypes of HCV were determined in 25 patients by INNO LiPA.RESULTS:
The overall prevalence of autoantibody was 65.5%. The most common autoantibody was aCL (34.5%), followed by ANA (25%), RF (18%), LA (15.5%), ASA (6.9%), anti-microsomal antibody (6%) and AMA (1%). The positive rate of either ANA or ASA was 30.2%, but both were positive in 1.7% only. There was no difference in the demographic features, biochemistry, HCV genotypes and disease status between autoantibody-positive and autoantibody-negative patients.CONCLUSIONS:
Autoantibodies were commonly found in patients with chronic HCV infection. But, the presence of autoantibodies may be a non-specific finding in chronic hepatitis C infection without clinical significance.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rheumatoid Factor
/
Autoantibodies
/
Autoimmune Diseases
/
Biochemistry
/
Prevalence
/
Hepacivirus
/
Hepatitis C, Chronic
/
Hepatitis, Autoimmune
/
Discrimination, Psychological
/
Genotype
Type of study:
Prevalence study
Limits:
Humans
Language:
Korean
Journal:
The Korean Journal of Hepatology
Year:
1999
Type:
Article
Similar
MEDLINE
...
LILACS
LIS