Effect of Rivaroxaban on Fibrinolytic Therapy in Massive Pulmonary Embolism: Two Cases / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 127-130, 2014.
Article
in English
| WPRIM
| ID: wpr-224803
ABSTRACT
The risk of dying from a pulmonary embolism (PE) is estimated to be about 30% if inotropic support is required and no cardiopulmonary arrest occurs. Fibrinolysis in massive PE is regarded as a life-saving intervention, unless there is a high risk of bleeding following the use of the fibrinolytic therapy. Rivaroxaban is an oral factor Xa inhibitor, however its anticoagulation effects before or after administration of fibrinolytics in massive PE are still unknown. Two patents were admitted 61-year-old woman with repeated syncope, and a 73-year-old woman was admitted with dyspnea and poor oral intake. Systemic arterial hypotension with radiologic confirmation led to a diagnosis of massive PE in both patients. Rivaroxaban was administered before in one, and after firbrinolytic therapy in the other. One showed similar efficacy of rivaroxaban with currently used anticoagulants after successful fibrinolysis, and the other one without antecedent administration of the fibrinolytic agent showed unfavorable efficacy of rivaroxaban.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pulmonary Embolism
/
Syncope
/
Factor Xa
/
Thrombolytic Therapy
/
Diagnosis
/
Dyspnea
/
Fibrinolysis
/
Rivaroxaban
/
Heart Arrest
/
Hemorrhage
Type of study:
Diagnostic study
Limits:
Aged
/
Female
/
Humans
Language:
English
Journal:
Tuberculosis and Respiratory Diseases
Year:
2014
Type:
Article
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