STN DBS of Advanced Parkinson's Disease Experienced in a Specialized Monitoring Unit with a Prospective Protocol
Journal of Korean Neurosurgical Society
;
: 26-35, 2008.
Article
in English
| WPRIM
| ID: wpr-224914
ABSTRACT
OBJECTIVE:
In the evaluation of patients with Parkinson's disease (PD), most neurologists only see their patients during a limited period of their fluctuating 24-hour-a-day lives. This study aimed to assess the short-term outcome of STN stimulation for patients with advanced PD evaluated in a 24-hour monitoring unit for movement disorder (MUMD) using a prospective protocol.METHODS:
Forty-two patients with advanced PD consecutively treated with bilateral STN stimulation using multi-channel microelectrode recording were included in this study. All patients were evaluated using a 24-hour MUMD with a video recording/editing system and were evaluated with a prospective protocol of the Unified Parkinson's Disease Rating Scale, Hoehn and Yahr Staging, Schwab and England Activities of Daily Living, levodopa equivalent daily dose (LEDD), Short Form-36 Health Survey, and neuropsychological tests. Magnetic resonance (MR) images of the brain were performed prior to and six months after surgery.RESULTS:
All patients were evaluated at three and six months after surgery. There was a rapid and significant improvement of the motor symptoms, especially in tremor and rigidity, after STN stimulation with low morbidity. Dyskinesia was markedly decreased with much lowered LEDD values by 50% after STN stimulation. 1.5T MR images were safely taken according to the manufacturer's guidelines at six months after surgery without any adverse effects in 41 patients treated with STN stimulations.CONCLUSION:
Evaluations in a 24-hour monitoring unit could reduce the dose of medication efficiently to an optimal level with patients'comfort and improve the clinical symptoms in harmony with STN stimulation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parkinson Disease
/
Tremor
/
Brain
/
Activities of Daily Living
/
Magnetic Resonance Spectroscopy
/
Levodopa
/
Prospective Studies
/
Health Surveys
/
Subthalamic Nucleus
/
Dyskinesias
Type of study:
Practice guideline
/
Observational study
/
Qualitative research
Limits:
Humans
Country/Region as subject:
Europa
Language:
English
Journal:
Journal of Korean Neurosurgical Society
Year:
2008
Type:
Article
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