Allergen Sensitization Pattern by Sex: A Cluster Analysis in Korea
Annals of Dermatology
; : 735-741, 2017.
Article
in En
| WPRIM
| ID: wpr-225298
Responsible library:
WPRO
ABSTRACT
BACKGROUND: Allergens tend to sensitize simultaneously. Etiology of this phenomenon has been suggested to be allergen cross-reactivity or concurrent exposure. However, little is known about specific allergen sensitization patterns. OBJECTIVE: To investigate the allergen sensitization characteristics according to gender. METHODS: Multiple allergen simultaneous test (MAST) is widely used as a screening tool for detecting allergen sensitization in dermatologic clinics. We retrospectively reviewed the medical records of patients with MAST results between 2008 and 2014 in our Department of Dermatology. A cluster analysis was performed to elucidate the allergen-specific immunoglobulin (Ig)E cluster pattern. RESULTS: The results of MAST (39 allergen-specific IgEs) from 4,360 cases were analyzed. By cluster analysis, 39items were grouped into 8 clusters. Each cluster had characteristic features. When compared with female, the male group tended to be sensitized more frequently to all tested allergens, except for fungus allergens cluster. CONCLUSION: The cluster and comparative analysis results demonstrate that the allergen sensitization is clustered, manifesting allergen similarity or co-exposure. Only the fungus cluster allergens tend to sensitize female group more frequently than male group.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Immunoglobulins
/
Allergens
/
Cluster Analysis
/
Mass Screening
/
Medical Records
/
Retrospective Studies
/
Dermatology
/
Fungi
/
Korea
Type of study:
Observational_studies
/
Prognostic_studies
/
Screening_studies
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
Annals of Dermatology
Year:
2017
Type:
Article