Predictors of Default from Treatment for Tuberculosis: a Single Center Case-Control Study in Korea
Journal of Korean Medical Science
;
: 254-260, 2016.
Article
in English
| WPRIM
| ID: wpr-225583
ABSTRACT
Default from tuberculosis (TB) treatment could exacerbate the disease and result in the emergence of drug resistance. This study identified the risk factors for default from TB treatment in Korea. This single-center case-control study analyzed 46 default cases and 100 controls. Default was defined as interrupting treatment for 2 or more consecutive months. The reasons for default were mainly incorrect perception or information about TB (41.3%) and experience of adverse events due to TB drugs (41.3%). In univariate analysis, low income (< 2,000 US dollars/month, 88.1% vs. 68.4%, P = 0.015), absence of TB stigma (4.3% vs. 61.3%, P < 0.001), treatment by a non-pulmonologist (74.1% vs. 25.9%, P < 0.001), history of previous treatment (37.0% vs. 19.0%, P = 0.019), former defaulter (15.2% vs. 2.0%, P = 0.005), and combined extrapulmonary TB (54.3% vs. 34.0%, P = 0.020) were significant risk factors for default. In multivariate analysis, the absence of TB stigma (adjusted odd ratio [aOR] 46.299, 95% confidence interval [CI] 8.078-265.365, P < 0.001), treatment by a non-pulmonologist (aOR 14.567, 95% CI 3.260-65.089, P < 0.001), former defaulters (aOR 33.226, 95% CI 2.658-415.309, P = 0.007), and low income (aOR 5.246, 95% CI 1.249-22.029, P = 0.024) were independent predictors of default from TB treatment. In conclusion, patients with absence of disease stigma, treated by a non-pulmonologist, who were former defaulters, and with low income should be carefully monitored during TB treatment in Korea to avoid treatment default.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Socioeconomic Factors
/
Tuberculosis
/
Case-Control Studies
/
Odds Ratio
/
Multivariate Analysis
/
Risk Factors
/
Medication Adherence
/
Republic of Korea
/
Antitubercular Agents
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2016
Type:
Article
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