A case of regression of atypical dense deposit disease without C3 deposition in a child / 소아과
Korean Journal of Pediatrics
;
: 766-769, 2010.
Article
in English
| WPRIM
| ID: wpr-225655
ABSTRACT
Dense deposit disease (DDD) is a rare disorder characterized by the deposition of abnormal electron-dense material within the glomerular basement membrane of the kidneys. The diagnosis is made in most patients between 5 and 15 years of age, and within 10 years, approximately half of the affected patients progress to end-stage renal disease. We report a rare case of regressive DDD without C3 deposition after steroid therapy in an 11-year-old boy. The patient presented with edema, gross hematuria, and nephrotic-range proteinuria. Laboratory testing revealed a serum creatinine level of 1.17 mg/dL, albumin level of 2.3 g/dL, and serum C3 level of 125 mg/dL (range 90-180 mg/dL). The results of the renal biopsy were consistent with DDD without C3 deposition. After 6 weeks of steroid therapy, the nephrotic syndrome completely resolved. The follow-up renal biopsy showed a significant reduction in mesangial proliferation and disappearance of electron-dense deposits in the GBM.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Proteinuria
/
Biopsy
/
Remission Induction
/
Glomerulonephritis, Membranoproliferative
/
Follow-Up Studies
/
Creatinine
/
Dichlorodiphenyldichloroethane
/
Edema
/
Glomerular Basement Membrane
/
Glomerulonephritis
Type of study:
Observational study
/
Prognostic study
Limits:
Child
/
Humans
Language:
English
Journal:
Korean Journal of Pediatrics
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS