New Aspects of Vascular Calcification: Histone Deacetylases and Beyond
Journal of Korean Medical Science
;
: 1738-1748, 2017.
Article
in English
| WPRIM
| ID: wpr-225701
ABSTRACT
Vascular calcification is a pathologic phenomenon in which calcium phosphate is ectopically deposited in the arteries. Previously, calcification was considered to be a passive process in response to metabolic diseases, vascular or valvular diseases, or even aging. However, now calcification is recognized as a highly-regulated consequence, like bone formation, and many clinical trials have been carried out to elucidate the correlation between vascular calcification and cardiovascular events and mortality. As a result, vascular calcification has been implicated as an independent risk factor in cardiovascular diseases. Many molecules are now known to be actively associated with this process. Recently, our laboratory found that posttranslational modification of histone deacetylase (HDAC) 1 is actively involved in the development of vascular calcification. In addition, we found that modulation of the activity of HDAC as well as its protein stability by MDM2, an HDAC1-E3 ligase, may be a therapeutic target in vascular calcification. In the present review, we overview the pathomechanism of vascular calcification and the involvement of posttranslational modification of epigenetic regulators.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteogenesis
/
Arteries
/
Aging
/
Histones
/
Cardiovascular Diseases
/
Protein Processing, Post-Translational
/
Calcium
/
Risk Factors
/
Mortality
/
Protein Stability
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2017
Type:
Article
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