+764 G/A Mutation of Inhibin-alpha Gene in Korean Patients with Idiopathic Premature Ovarian Failure / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 1706-1711, 2006.
Article
in Korean
| WPRIM
| ID: wpr-225845
ABSTRACT
OBJECTIVE:
To evaluate the incidence of the +769 G/A mutation of inhibin-alpha gene in Korean patients with idiopathic premature ovarian failure.DESIGN:
DNA analysis of the mutation.METHODS:
One hundred patients with idiopathic premature ovarian failure (POF) were recruited. Patient with known causes of premature ovarian failure were excluded cytogenetic abnormalities, prior chemotherapy, prior bilateral oophorectomy and autoimmune disease, etc. DNA was extracted from peripheral blood and the +769 G/A variant of Inhibin-alpha gene (INH-alpha) was analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism using restriction enzyme BbvI.RESULTS:
We didn't find any case of +769 G/A variant in Inhibin-alpha gene in 100 Korean patients with idiopathic POF.CONCLUSION:
This result suggests that in contrary to the recent data reported on the Asian population, the +769 G/A variant in inhibin-alpha gene may not exist in Korean patients with idiopathic POF.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autoimmune Diseases
/
Polymorphism, Restriction Fragment Length
/
DNA
/
Ovariectomy
/
Polymerase Chain Reaction
/
Incidence
/
Chromosome Aberrations
/
Primary Ovarian Insufficiency
/
Asian People
/
Drug Therapy
Type of study:
Incidence study
/
Prognostic study
Limits:
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2006
Type:
Article
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