Prognostic factors associated with local recurrence in squamous cell carcinoma of the vulva / 부인종양
Journal of Gynecologic Oncology
;
: 242-248, 2013.
Article
in English
| WPRIM
| ID: wpr-225937
ABSTRACT
OBJECTIVE:
To analyze the prognostic factors related to the recurrence rate of vulvar cancer.METHODS:
Retrospective study of 87 patients diagnosed of vulvar squamous cell carcinoma diagnosed at a tertiary hospital in Madrid between January 2000 and December 2010.RESULTS:
The pathological mean tumor size was 35.1+/-22.8 mm, with stromal invasion of 7.7+/-6.6 mm. The mean free margin after surgery was 16.8+/-10.5 mm. Among all patients, 31 (35.6%) presented local recurrence (mean time 10 months; range, 1 to 114 months) and 7 (8%) had distant metastases (mean time, 5 months; range, 1 to 114 months). We found significant differences in the mean tumor size between patients who presented a relapse and those who did not (37.6+/-21.3 mm vs. 28.9+/-12.1 mm; p=0.05). Patients with free margins equal or less than 8 mm presented a relapse rate of 52.6% vs. 43.5% of those with free margin greater than 8 mm (p=0.50). However, with a cut-off of 15 mm, we observed a local recurrence rate of 55.6% vs. 34.5%, respectively (p=0.09). When the stromal invasion cut-off was >4 mm, local recurrence rate increased up to 52.9% compared to 37.5% when the stromal invasion was 4 mm, high risk predictors of local recurrence rate.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Vulva
/
Carcinoma, Squamous Cell
/
Retrospective Studies
/
Tertiary Care Centers
/
Neoplasm Metastasis
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Journal of Gynecologic Oncology
Year:
2013
Type:
Article
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