Expression of Caspase-3 and c-myc in Non-Small Cell Lung Cancer / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 303-307, 2004.
Article
in English
| WPRIM
| ID: wpr-226065
ABSTRACT
PURPOSE:
Caspase-3 is a cysteine protease that plays an important role in the process of apoptotic cell death, but little has been studied clinically on caspase-3 in lung cancer. Increased c-myc expression can result in mitosis or apoptosis, and its contribution to the pathogenesis and prognosis of lung cancer has gained interest. In the present study, the expressions of caspase-3 and c-myc, along with their possible correlations with prognostic variables, were analyzed in resected non-small cell lung carcinomas (NSCLC). MATERIALS ANDMETHODS:
Archival tumor tissues from 147 previously untreated NSCLC patients were examined by immunohistochemistry for the expressions of caspase-3 and c-myc proteins. Clinical information was obtained through the computerized retrospective database from the tumor registry.RESULTS:
The expressions of caspase-3 and c-myc were detected in 60 (88/147) and 16% (24/147) of tumors, respectively. No association was found between caspase-3 and c-myc expressions. A multivariate analysis demonstrated the N status and pathologic stage to be significantly correlated with poor survival (p-value=.018 and .002, respectively), but positive expression of caspase-3 was associated with a good prognosis (p=.03).CONCLUSION:
Our data suggest the involvement of caspase-3 in the tumorigenesis of NSCLC. It is also noteworthy that caspase-3 expression might be a favorable prognostic indicator in these tumors.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Immunohistochemistry
/
Multivariate Analysis
/
Retrospective Studies
/
Proto-Oncogene Proteins c-myc
/
Cell Death
/
Apoptosis
/
Carcinoma, Non-Small-Cell Lung
/
Caspase 3
/
Cysteine Proteases
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Cancer Research and Treatment
Year:
2004
Type:
Article
Similar
MEDLINE
...
LILACS
LIS