Physicians' preferences and perceptions regarding donor selection in allogeneic stem cell transplantation in Korea when a matched domestic donor is not available
Blood Research
; : 31-36, 2017.
Article
in En
| WPRIM
| ID: wpr-226885
Responsible library:
WPRO
ABSTRACT
BACKGROUND: A number of alternative donor options exist for patients who fail to find domestic HLA-matched donors for allogeneic hematopoietic stem cell transplantation (allo-HSCT). We assessed physicians' perspectives on allo-HSCT donor selection when a matched domestic donor is not available. METHODS: We administered a questionnaire survey to 55 hematologists (response rate: 28%) who attended the annual spring conference of the Korean Society of Haematology in 2015. The questionnaire contained four clinical allo-HSCT scenarios and the respondents were asked to choose the most preferred donor among the given options. RESULTS: In all four scenarios, the hematologists preferred a matched international donor over partially mismatched unrelated domestic or haplo-matched family donors. The numbers of hematologists who chose a matched international donor (HLA 8/8) in cases of acute myeloid leukemia, chronic myeloid leukemia, acute lymphoblastic leukemia, and aplastic anemia were 37 (67.3%), 41 (74.6%), 33 (60.0%), and 36 (65.5%), respectively. The important factors that affected donor selection included “expecting better clinical outcomes (40.5%)” and “lower risk of side effects (23.4%).” The majority of participants (80%) responded that allo-HSCT guidelines for donor selection customized for the Korean setting are necessary. CONCLUSION: Although hematologists still prefer perfectly matched foreign donors when a fully matched domestic allo-HSCT donor is not available, we confirmed that there was variation in their responses. For evidence-based clinical practice, it is necessary to provide further comparative clinical evidence on allo-HSCT from haplo-matched family donors and fully matched unrelated international donors.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Stem Cells
/
Tissue Donors
/
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/
Leukemia, Myeloid, Acute
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Surveys and Questionnaires
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Hematopoietic Stem Cell Transplantation
/
Stem Cell Transplantation
/
Donor Selection
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Unrelated Donors
Type of study:
Guideline
/
Qualitative_research
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Blood Research
Year:
2017
Type:
Article