Concurrent Large Cell Neuroendocrine Carcinoma and Adenocarcinoma of the Ascending Colon: A Case Report
Journal of the Korean Society of Coloproctology
;
: 157-161, 2011.
Article
in English
| WPRIM
| ID: wpr-226911
ABSTRACT
Large cell neuroendocrine carcinomas of the colon are rare and represent only a small percentage of all colonic endocrine tumors. Here, we report a case of a colonic large cell neuroendocrine carcinomas concurrent with a colonic adenocarcinoma. A 70-year-old man presented with acute abdominal pain. A spiral computed tomography scan of the abdomen revealed eccentric wall thickening on the ascending colon. An explorative laparotomy and a right hemicolectomy were performed. Grossly, two separated masses were observed in the proximal ascending colon. One was a 7.4 x 5.1 cm ulcerative fungating lesion, and the other was a 2.8 x 1.9 cm polypoid lesion. Microscopically, the ulcerative fungating lesion showed a well-differentiated neuroendocrine morphology with necrosis and increased mitosis. Most of the tumor cells had large, vesicular nuclei with eosinophilic nucleoli, variable amounts of eosinophilic cytoplasm, and immunoreactivity for chromogranin A and synaptophysin. The polypoid lesion was a well-differentiated adenocarcinoma that had invaded the submucosa. We diagnosed these lesions as a concurrent large cell neuroendocrine carcinoma and an adenocarcinoma of the ascending colon.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ulcer
/
Adenocarcinoma
/
Abdominal Pain
/
Synaptophysin
/
Colon
/
Colonic Neoplasms
/
Carcinoma, Neuroendocrine
/
Cytoplasm
/
Tomography, Spiral Computed
/
Colon, Ascending
Limits:
Aged
/
Humans
Language:
English
Journal:
Journal of the Korean Society of Coloproctology
Year:
2011
Type:
Article
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