A case of Stevens-Johnson syndrome caused by oxcarbazepine / 대한내과학회지
Korean Journal of Medicine
;
: 586-590, 2006.
Article
in Korean
| WPRIM
| ID: wpr-227050
ABSTRACT
Stevens-Johnson syndrome and toxic epidermal necrolysis are acute life-threatening conditions. Aromatic antiepileptic drugs such as carbamazepine, phenytoin and phenobarbital are frequently associated with severe adverse cutaneous reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis. Oxcarbazepine, a 10-keto derivative of carbamazepine has been reported to have a similar range of efficacy and fewer side effects than carbamazepine because it is a prodrug of a monohydroxy derivative. Because there are few clinical records of oxcarbazepine induced erythemamultiforme-like skin eruptsions, we reported a case of Stevens-Johnson syndrome thought to be caused by the use of oxcarbazepine in a 66-year-old male. Diffuse erythematous maculopapular eruptions were developed on his whole body 30 days after beginning with oxcarbazepine. The clinical and histologic findings of the patient were compatible with Stevens-Johnson syndrome. Although it is rare, oxcarbazepine can cause severe adverse cutaneous reactions.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenobarbital
/
Phenytoin
/
Skin
/
Carbamazepine
/
Stevens-Johnson Syndrome
/
Anticonvulsants
Limits:
Aged
/
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2006
Type:
Article
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