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Expression of p53 and MDM-2 Protein in Cervical Neoplasia / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology ; : 2264-2269, 1999.
Article in Korean | WPRIM | ID: wpr-227079
ABSTRACT

OBJECTIVES:

MDM-2 is an oncoprotein that inhibits p53 tumor suppressor protein. Amplication and over- expression of its protein have been observed in human malignancies, and these abnormalities have a role in tumorigenesis through inactivation of p53 function. To elucidate the role of p53 and MDM-2 protein in cervical neoplasia we investigated the expression rates of MDM-2 and p53 protein in surgically resected specimens. METHEDS Immunohistochemical studies using anti-p53 and anti-MDM-2 protein in the paraffin embedded section of 62 cases including cervical intraepithelial neoplasm(CIN) and invasive cervical cancer were performed.

RESULTS:

Expression rates of p53 protein were 25% in CIN I& CINII, 20% in CINIII, and 44% in invasive carcinoma, respectively. The MDM-2 protein were 33% in CIN I & CIN II, 16% in CIN III, and 48% in invasive carcinoma, respectively. There was no evident correlation between p53 positivity and MDM-2 positivity(p>0.05). However, correlation between MDM-2 negativity and p53 negativity was statistically significant(p=0.002)

CONCLUSION:

These data suggest that the expression of p53 protein is presumed to be necessarily correlated with MDM-2 protein expression in cervical neoplasia.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Paraffin / Uterine Cervical Neoplasms / Tumor Suppressor Protein p53 / Proto-Oncogene Proteins c-mdm2 / Carcinogenesis Limits: Humans Language: Korean Journal: Korean Journal of Obstetrics and Gynecology Year: 1999 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Paraffin / Uterine Cervical Neoplasms / Tumor Suppressor Protein p53 / Proto-Oncogene Proteins c-mdm2 / Carcinogenesis Limits: Humans Language: Korean Journal: Korean Journal of Obstetrics and Gynecology Year: 1999 Type: Article