What Is the Ideal Core Number for Ultrasound-Guided Prostate Biopsy?
Korean Journal of Urology
;
: 725-731, 2014.
Article
in English
| WPRIM
| ID: wpr-227273
ABSTRACT
PURPOSE:
We evaluated the utility of 10-, 12-, and 16-core prostate biopsies for detecting prostate cancer (PCa) and correlated the results with prostate-specific antigen (PSA) levels, prostate volumes, Gleason scores, and detection rates of high-grade prostatic intraepithelial neoplasia (HGPIN) and atypical small acinar proliferation (ASAP). MATERIALS ANDMETHODS:
A prospective controlled study was conducted in 354 consecutive patients with various indications for prostate biopsy. Sixteen-core biopsy specimens were obtained from 351 patients. The first 10-core biopsy specimens were obtained bilaterally from the base, middle third, apex, medial, and latero-lateral regions. Afterward, six additional punctures were performed bilaterally in the areas more lateral to the base, middle third, and apex regions, yielding a total of 16-core biopsy specimens. The detection rate of carcinoma in the initial 10-core specimens was compared with that in the 12- and 16-core specimens.RESULTS:
No significant differences in the cancer detection rate were found between the three biopsy protocols. PCa was found in 102 patients (29.06%) using the 10-core protocol, in 99 patients (28.21%) using the 12-core protocol, and in 107 patients (30.48%) using the 16-core protocol (p=0.798). The 10-, 12-, and 16-core protocols were compared with stratified PSA levels, stratified prostate volumes, Gleason scores, and detection rates of HGPIN and ASAP; no significant differences were found.CONCLUSIONS:
Cancer positivity with the 10-core protocol was not significantly different from that with the 12- and 16-core protocols, which indicates that the 10-core protocol is acceptable for performing a first biopsy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostate
/
Prostatic Neoplasms
/
Rectum
/
Prospective Studies
/
Reproducibility of Results
/
Follow-Up Studies
/
Prostate-Specific Antigen
/
Prostatic Intraepithelial Neoplasia
/
Endosonography
/
Cell Proliferation
Type of study:
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Humans
/
Male
Language:
English
Journal:
Korean Journal of Urology
Year:
2014
Type:
Article
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