Increased Nephrotoxicity after Combined Administration of Melamine and Cyanuric Acid in Rats / 한국실험동물학회지
Laboratory Animal Research
;
: 25-28, 2011.
Article
in English
| WPRIM
| ID: wpr-227298
ABSTRACT
Renal toxicity by melamine in combination with cyanuric acid (11) was investigated. Male rats were orally administered melamine plus cyanuric acid (5, 50 or 400 mg/kg each) for 3 days. In contrast to a negligible effect by melamine alone (50 mg/kg, a no-observed-adverse-effect-level NOAEL), co-administration with cyanuric acid markedly increased the concentrations of blood urea nitrogen and creatinine, as well as kidney weight. A high dose (400 mg/kg) of melamine plus cyanuric acid induced more severe kidney toxicity. The increased blood parameters for kidney toxicity and organ weight lasted longer than 4 days. Combined treatment with melamine and cyanuric acid (50-400 mg/kg each) resulted in many gold-brown crystals and toxic lesions in renal tubules, which were not observed in animals treated with melamine alone (50 mg/kg). These results indicate that only a 3-day exposure to melamine in combination with cyanuric acid causes severe renal damage, even at a NOAEL for melamine found in a 13-week toxicity study. Therefore, it is suggested that the tolerable daily intake or regulatory/management levels of melamine need to be re-considered for cases of co-exposure with cyanuric acid.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organ Size
/
Triazines
/
Blood Urea Nitrogen
/
No-Observed-Adverse-Effect Level
/
Creatinine
/
Kidney
Limits:
Animals
/
Humans
/
Male
Language:
English
Journal:
Laboratory Animal Research
Year:
2011
Type:
Article
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