Study of Empirical Antifungal Therapy in Febrile Neutropenia and Invasive Fungal Infection after Introduction of Novel Antifungal Agents / 대한의진균학회지
Korean Journal of Medical Mycology
;
: 177-181, 2009.
Article
in Korean
| WPRIM
| ID: wpr-227376
ABSTRACT
BACKGROUND:
Patients with prolonged empirical broad spectrum antibiotics for febrile neutropenia (FN) with cancer, inevitably have increased risk of invasive fungal infections owing to the altered endogenous microbial environment.OBJECTIVE:
The purpose of this study is to evaluate the impact of empirical antifungal therapy on occurrence of invasive fungal infections (IFIs) during FN with cancer.METHODS:
We retrospectively reviewed medical records of patients with FN after cytotoxic chemotherapy due to cancer from July, 2003 to June, 2007.RESULTS:
We identified 91 patients with FN after cytotoxic chemotherapy. Most common underlying conditions were lymphoma (20/91, 22%) and leukemia (20/91, 22%). IFIs occurred in 10% (9/91). In a comparison of patients with empirical antifungal therapy with no antifungal therapy, the duration of neutropenia was significantly increased with IFIs (p=0.09). The mortality of IFIs was 55.5% (5/9).CONCLUSION:
We found that the duration of FN than empirical antifungal therapy affected occurrence of IFIs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Leukemia
/
Medical Records
/
Retrospective Studies
/
Lymphoma
/
Anti-Bacterial Agents
/
Antifungal Agents
/
Neutropenia
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Medical Mycology
Year:
2009
Type:
Article
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