A Case of Hypersensitivity Reaction Induced by Abacavir in an AIDS Patient / 대한내과학회지
Korean Journal of Medicine
;
: 136-140, 2012.
Article
in Korean
| WPRIM
| ID: wpr-227526
ABSTRACT
Abacavir is a nucleoside reverse transcriptase inhibitor that is commonly used in HIV-infected patients. A well-known and potentially life-threatening side effect of abacavir is allergic hypersensitivity reaction. A screening test for the HLA-B*5701 allele is currently used to predict the risk of hypersensitivity reaction to abacavir. This test, however, may be less useful in Korea, because of the low prevalence of HLA-B*5701. A 52-year-old male with HIV infection was referred to our hospital because of suspected side-effects of antiviral agents and lymph node enlargement of the neck. He suffered from a fever, generalized edema, skin rash of the whole body, and difficulty breathing after starting antiviral agents. Suspected as a hypersensitivity reaction resulting from drug side-effects, prescription of abacavir was stopped. The patient subsequently recovered. The presence of the HLA-B*5701 allele was confirmed by polymerase chain reaction-sequencing based typing (PCR-SBT).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Antiviral Agents
/
Respiration
/
Dideoxynucleosides
/
HLA-B Antigens
/
HIV Infections
/
Mass Screening
/
Prevalence
/
RNA-Directed DNA Polymerase
/
Edema
/
Alleles
Type of study:
Prevalence study
/
Prognostic study
/
Screening study
Limits:
Humans
/
Male
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2012
Type:
Article
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