Differences in Expression of VEGF-A, VEGFR-1, VEGFR-2 and Microvessel Density in Colorectal Cancer with Liver Metastasis
Korean Journal of Pathology
;
: 571-580, 2010.
Article
in Korean
| WPRIM
| ID: wpr-227767
ABSTRACT
BACKGROUND:
Colorectal cancer (CRC) is one of the most common malignant neoplasms and is a leading cause of mortality worldwide. Metastasis to the liver is a frequent event in patients with CRC. An essential step in the metastatic cascade is angiogenesis.METHODS:
This study included 45 patients who underwent a partial colectomy with hepatic resection for CRC with hepatic metastases. Immunohistochemistry was performed using vascular endothelial growth factor (VEGF)-A, VEGF receptor (VEGFR)-1, VEGFR-2, and CD34 antibodies to examine the relationship between CRC with liver metastases and angiogenesis.RESULTS:
CRC showed significantly stronger expression of VEGF-A, VEGFR-1, and VEGFR-2 than liver metastases (p < 0.05). Microvessel density was also higher in CRC than in liver metastases (p < 0.05).CONCLUSIONS:
Compared with previous studies, we found a higher expression of VEGF-A, VEGFR-1, VEGFR-2, and microvessel density in CRC than in liver metastases, which could be ascribed to a difference in vessel distribution and blood supply in each organ. Given its profuse blood supply and distinct cell populations, the liver might provide a rich milieu for tumor cell growth with less expression of angiogenesis-inducing agents.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thymus Gland
/
World Health Organization
/
Immunohistochemistry
/
Colorectal Neoplasms
/
Colectomy
/
Receptors, Vascular Endothelial Growth Factor
/
Vascular Endothelial Growth Factor Receptor-1
/
Vascular Endothelial Growth Factor Receptor-2
/
Vascular Endothelial Growth Factor A
/
Microvessels
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Pathology
Year:
2010
Type:
Article
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