The Study of Pathologic Difference between Endoscopic Biopsy before EMR and Histology of Specimen after Endoscopic Mucosal Resection (EMR) on Gastric Flat Adenoma or Early Gastric Cancer (EGC) / 대한소화기내시경학회지

ABSTRACT

BACKGROUND/AIMS: It is not uncommon to show discrepancy between the histology of the endoscopic biopsy and that of the resected specimen obtained from the same lesion by EMR. The aim of this study was to ascertain whether routine endoscopic biopsy specimens are sufficient to qualify the representative enough to reliable indication of EMR. METHODS: We retrospectively reviewed 36 cases that could be compared the histologic results from the resected specimens by EMR to the tissue obtained by endoscopic biopsy. The histologic slides were reviewed by one pathologist. RESULTS: Of the 36 cases, 13 cases of EGC and 23 cases of gastric flat adenomas were included. Among 13 cases of EGC, 2 case (15.4%) revealed discrepancy between the histology of the endoscopic biopsy and that of a resected specimen by EMR. The histology of a resected specimen by EMR revealed moderate differentiated adenocarcinoma, while that of endoscopic biopsy was a well differentiated adenocarcinoma. Gastric flat adenoma revealed 47.8% (11/23) of discrepancy. CONCLUSIONS: The histologic discrepancy between the result of endoscopic biopsy and that of the resected specimen obtained by EMR was about 8% in EGC and 47.8% in gastric flat adenoma.