A Preliminary Report of Busulfan, Melphalan and Thiotepa or TBI-containing Bi-alkylator Chemotherapy as a Preparative Regimen for Allogeneic Bone Marrow Transplantation in Refractory or Relapsed Acute Leukemias / 대한암학회지
Journal of the Korean Cancer Association
;
: 874-885, 1997.
Article
in Korean
| WPRIM
| ID: wpr-227990
ABSTRACT
PURPOSE:
We assessed the three-alkylator combination of busulfan, melphalan and thiotepa or TBI, melphalan and thiotepa conditioning for allogeneic stem cell transplantation in 7 adult patients with refractory or relapsed acute leukemias. MATERIALS ANDMETHODS:
Six patients were transplanted for acute myeloid leukemia, one for acute lymphoblastic leukemia and included 5 of relapsed refractory, 2 of relapsed after first-BMT. All but 1 cases received G-CSF stimulated CD34+ allogeneic peripheral blood progenitor cells (PBPCs) in addition to stimulated allogeneic marrow.RESULTS:
All patients except one engrafted (median time to ANC >0.5 10 (9)/L=11days, to platelets >30 X 10 (9)/L=14 days) successfully and complete remission was obtained in 6 patients. Grade I-II acute GVHD and controllable regimen-related toxicity especially oral mucositis (grade II-III) developed in all cases, but 2 patients including one second- allogeneic BMT patient expired early by transplant-related toxicity of hepatic or multiorgan failure along the course of sepsis.CONCLUSION:
Although the observation period on these cases are limited, the data presented show that the combination of busulfan, melphalan and thiotepa is tolerable as a preparative regimen for allogeneic marrow transplantation in high-risk leukemic patients. We think that these encouraging results need to be confirmed in prospective studies in the future.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stem Cells
/
Stomatitis
/
Bone Marrow
/
Busulfan
/
Leukemia, Myeloid, Acute
/
Leukemia
/
Granulocyte Colony-Stimulating Factor
/
Bone Marrow Transplantation
/
Thiotepa
/
Sepsis
Type of study:
Observational study
Limits:
Adult
/
Humans
Language:
Korean
Journal:
Journal of the Korean Cancer Association
Year:
1997
Type:
Article
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