Detection of Intrahepatic HBV DNA in HBsAg-negative Liver Diseases / 대한간학회지
The Korean Journal of Hepatology
;
: 201-208, 2006.
Article
in Korean
| WPRIM
| ID: wpr-228077
ABSTRACT
BACKGROUNDS/AIMS:
Occult HBV infection is characterized by the presence of HBV infection with undetectable HBsAg. This study was carried out to find out the frequency of HBV infection in HBsAg- negative patients.METHODS:
Fifty-six HBsAg-negative patients including 17 anti-HCV positive patients were evaluated. Patients were grouped according to their serological status; group A (anti-HBc+, anti-HBs-, n=16), B (anti-HBc+, anti-HBs+, n=26), and C (anti-HBc-, anti-HBs+/-, n=14). DNA was extracted from frozen liver biopsy specimen, and HBV DNA level was measured with real-time PCR.RESULTS:
Overall frequency of detectable intrahepatic HBV DNA was 34% (19/56). The frequency was 56% (9/16) in group A, 31% (8/26) in group B and 14% (2/14) in group C (P=0.01). Intrahepatic HBV DNA levels were as follows; 2,010 +/- 6,660 copies/mg in group A, 6,180 +/- 29,530 copies/mg in group B and 350 +/- 1,220 copies/mg in group C. The frequency of occult HBV infection was not increased in anti-HCV positive patients.CONCLUSIONS:
Intrahepatic HBV DNA is frequently detected in anti-HBc positive, HBsAg-negative patients, although the concentration is low.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
DNA, Viral
/
Hepatitis B virus
/
Hepatitis B
/
Hepatitis B Surface Antigens
/
Liver
Type of study:
Diagnostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Korean
Journal:
The Korean Journal of Hepatology
Year:
2006
Type:
Article
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