Natural History of HBeAg Negative Chronic Hepatitis B Virus Infection: A Cohort Study / 대한간학회지
The Korean Journal of Hepatology
;
: 163-172, 2006.
Article
in Korean
| WPRIM
| ID: wpr-228081
ABSTRACT
BACKGROUND/AIMS:
The long-term virologic and biochemical changes in patients with HBeAg negative HBV infection, especially in Asia, remain unclear. To address this issue, we conducted a 3 year- retrospective, cohort study.METHODS:
A total of 157 patients with HBeAg negative HBV infection who were monitored without treatment were reviewed between January 1999 and March 2004. Those patients were followed up every 3 months with liver function tests and serologic tests. All patients were stratified into 3 groups; inactive carrier (IC), viremic carrier (VC) and chronic hepatitis (CH). Serum HBV DNA was measured by a hybridization assay (sensitivity 1.4 x 10(5) genomes/mL, Digene Diagnostics, Silver Spring, USA).RESULTS:
The median age of enrolled patients was 42.7 years (MF=2.31). By single time-point observations, the 3 year-cohort prevalence of HBeAg negative CH varied from 12.7 to 35.8% (median 20.7%) HBeAg negative CH was accumulated over time (P=0.002) and transition rates among three groups after 3 years of follow-up are as follows IC to CH, 6.0%; IC to VC, 4.1%; VC to CH, 23.2%. VC seems to be a disease state in the middle of transition from IC to CH.CONCLUSIONS:
We demonstrated the dynamic changing patterns of HBeAg negative CH with time, of which the change from IC or VC to CH was dominant.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Carrier State
/
Hepatitis B, Chronic
/
Hepatitis B e Antigens
Type of study:
Etiology study
/
Observational study
/
Prognostic study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Korean
Journal:
The Korean Journal of Hepatology
Year:
2006
Type:
Article
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