The Role of the Glutamate Receptor in the Transient Focal Cerebral Ischemia in Rats / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 1062-1067, 2000.
Article
in Korean
| WPRIM
| ID: wpr-228354
ABSTRACT
BACKGROUND:
To investigate the role of glutamate in the transient focal cerebral ischemia, a reversible middle cerebral artery occlusion model was induced in 25 male Sprague-Dawley rats.METHODS:
Triphenyltetrazolium chloride (TTC) stain was used for evaluation of the changes of infarction ratio in MK-801 (0.3, 1.0, 3.0 mg/kg) or pentylenetetrazole (50 mg/kg) treated groups.RESULT:
The infarction ratio at 48 hours after 2 hour transient focal brain ischemia was 39.2 +/- 13.2% in control group and 23.8 +/- 4.2, 27.0 +/- 8.9, and 12.8 +/- 4.4% in MK-801 (0.3, 1.0, 3.0 mg/kg) groups. In the pentylenetetrazole (PTZ) group, the infarction ratio was 32.6 +/- 6.7%.CONCLUSIONS:
The non-specific glutamate receptor antagonist, MK-801, showed a trend toward dose-dependent improvement, but the PTZ group showed no improvement. From these results, it suggested that glutamate might be partly involved in the mechanisms of ischemia-induced neuronal damage.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pentylenetetrazole
/
Brain Ischemia
/
Dizocilpine Maleate
/
Receptors, Glutamate
/
Rats, Sprague-Dawley
/
Glutamic Acid
/
Infarction, Middle Cerebral Artery
/
Infarction
/
Neurons
Limits:
Animals
/
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2000
Type:
Article
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