Your browser doesn't support javascript.
loading
Adequate Combination of Target Effect-site Concentration of Propofol and Remifentanil for Tracheal Intubation / 대한마취과학회지
Korean Journal of Anesthesiology ; : 37-42, 2008.
Article in Korean | WPRIM | ID: wpr-228398
ABSTRACT

BACKGROUND:

We wanted to determine an adequate combination of target effect-site concentrations of remifentanil and propofol during anesthetic induction with target controlled infusion (TCI).We also determined whether increasing remifentanil concentrations might reduce propofol consumption at loss of consciousness (LOC).

METHODS:

Sixty ASA 1 or 2 patients were randomly allocated according to the target effect-site concentration of remifentanil and propofol (R7P3 remifentanil 7 ng/ml + propofol 3microgram/ml, R5P4 remifentanil 5 ng/ml + propofol 4microgram/ml, R3P5 remifentanil 3 ng/ml + propofol 5microgram/ml). After the target effect-site concentration of remifentanil had been reached, the TCI of propofol was started. The effect-site concentration of propofol at LOC was recorded. When the target effect-site concentration of propofol was reached, 0.6 mg/kg of rocuronium was administered. Tracheal intubation was performed after 2 minutes. The noninvasive blood pressure, heart rate (HR), bispectral index (BIS), and infused dose of remifentanil and propofol were recorded.

RESULTS:

R3P5 groupd showed a significant increase in mean blood pressure after intubation (104 +/- 31.9 mmHg, P < 0.05) compared to R7P3 and R5P4. BIS at the time when propofol reached its target effect-site concentration was significantly higher in the R7P3 group (71.6 +/- 9.9, P < 0.05 compared to R5P4 and R3P5). There was a significant relationship between the effect-site concentration of remifentanil and propofol at LOC (Y = 2.032 - 0.351X, R(2) = 0.551, P < 0.0001).

CONCLUSIONS:

The R5P4 target effect-site concentrations are adequate dosing combinations during TCI induction based on hemodynamic responses and BIS values.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Piperidines / Unconsciousness / Blood Pressure / Propofol / Heart Rate / Hemodynamics / Androstanols / Intubation Limits: Humans Language: Korean Journal: Korean Journal of Anesthesiology Year: 2008 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Piperidines / Unconsciousness / Blood Pressure / Propofol / Heart Rate / Hemodynamics / Androstanols / Intubation Limits: Humans Language: Korean Journal: Korean Journal of Anesthesiology Year: 2008 Type: Article