Adequate Combination of Target Effect-site Concentration of Propofol and Remifentanil for Tracheal Intubation / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 37-42, 2008.
Article
in Korean
| WPRIM
| ID: wpr-228398
ABSTRACT
BACKGROUND:
We wanted to determine an adequate combination of target effect-site concentrations of remifentanil and propofol during anesthetic induction with target controlled infusion (TCI).We also determined whether increasing remifentanil concentrations might reduce propofol consumption at loss of consciousness (LOC).METHODS:
Sixty ASA 1 or 2 patients were randomly allocated according to the target effect-site concentration of remifentanil and propofol (R7P3 remifentanil 7 ng/ml + propofol 3microgram/ml, R5P4 remifentanil 5 ng/ml + propofol 4microgram/ml, R3P5 remifentanil 3 ng/ml + propofol 5microgram/ml). After the target effect-site concentration of remifentanil had been reached, the TCI of propofol was started. The effect-site concentration of propofol at LOC was recorded. When the target effect-site concentration of propofol was reached, 0.6 mg/kg of rocuronium was administered. Tracheal intubation was performed after 2 minutes. The noninvasive blood pressure, heart rate (HR), bispectral index (BIS), and infused dose of remifentanil and propofol were recorded.RESULTS:
R3P5 groupd showed a significant increase in mean blood pressure after intubation (104 +/- 31.9 mmHg, P < 0.05) compared to R7P3 and R5P4. BIS at the time when propofol reached its target effect-site concentration was significantly higher in the R7P3 group (71.6 +/- 9.9, P < 0.05 compared to R5P4 and R3P5). There was a significant relationship between the effect-site concentration of remifentanil and propofol at LOC (Y = 2.032 - 0.351X, R(2) = 0.551, P < 0.0001).CONCLUSIONS:
The R5P4 target effect-site concentrations are adequate dosing combinations during TCI induction based on hemodynamic responses and BIS values.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Piperidines
/
Unconsciousness
/
Blood Pressure
/
Propofol
/
Heart Rate
/
Hemodynamics
/
Androstanols
/
Intubation
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2008
Type:
Article
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