Prognostic factors of neurological outcomes in late-preterm and term infants with perinatal asphyxia / 소아과
Korean Journal of Pediatrics
;
: 440-445, 2016.
Article
in English
| WPRIM
| ID: wpr-228479
ABSTRACT
PURPOSE:
This study aimed to identify prognostic factors of neurological outcomes, including developmental delay, cerebral palsy and epilepsy in late-preterm and term infants with perinatal asphyxia.METHODS:
All late-preterm and term infants with perinatal asphyxia or hypoxic-ischemic insults who admitted the neonatal intensive care unit of Inje University Sanggye Paik Hospital between 2006 and 2014 and were followed up for at least 2 years were included in this retrospective study. Abnormal neurological outcomes were defined as cerebral palsy, developmental delay and epilepsy.RESULTS:
Of the 114 infants with perinatal asphyxia, 31 were lost to follow-up. Of the remaining 83 infants, 10 died, 56 had normal outcomes, and 17 had abnormaloutcomes:
14 epilepsy (82.4%), 13 cerebral palsy (76.5%), 16 developmental delay (94.1%). Abnormal outcomes were significantly more frequent in infants with later onset seizure, clinical seizure, poor electroencephalography (EEG) background activity, lower Apgar score at 1 and 5 minutes and abnormal brain imaging (P<0.05). Infants with and without epilepsy showed significant differences in EEG background activity, clinical and electrographic seizures on EEG, Apgar score at 5 minutes and brain imaging findings.CONCLUSION:
We should apply with long-term video EEG or amplitude integrated EEG in order to detect and management subtle clinical or electrographic seizures in neonates with perinatal asphyxia. Also, long-term, prospective studies with large number of patients are needed to evaluate more exact prognostic factors in neonates with perinatal asphyxia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Apgar Score
/
Asphyxia
/
Seizures
/
Brain
/
Intensive Care, Neonatal
/
Cerebral Palsy
/
Prospective Studies
/
Retrospective Studies
/
Electroencephalography
/
Epilepsy
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
/
Infant
/
Infant, Newborn
Language:
English
Journal:
Korean Journal of Pediatrics
Year:
2016
Type:
Article
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