Pharmacokinetics of ofloxacin in Patients with Multidrug-Resistant Tuberculosis / 결핵
Tuberculosis and Respiratory Diseases
;
: 128-136, 2002.
Article
in Korean
| WPRIM
| ID: wpr-228590
ABSTRACT
BACKGROUND:
There are few studies that have reported on the pharmacokinetic(PK) disposition of fluoroquinolones in patients with multi-drug resistant tuberculosis(MDR-Tb), even though fluoroquinolones are frequentl y co-prescribed to those patients. In this study, the PK disposition of ofloxacin, a fluoroquinolone, was evaluated in patients with MDR-Tb.METHODS:
Twenty patients with MDR-Tb were given 2nd line Tb drugs including ofloxacin (300mg twice a day), prothionamide, cycloserine, para-aminosalicylic acid, kanamycin, and streptomycin. The patients were grouped according to their body mass index(BMI) as an index of emaciation (group A 18.5RESULTS:
The AUC of ofloxacin in group B was greater than that in group A (31.4+/-8.9micro gram/ml.h vs. 24.1+/-6.2micro gram/ml.h)(Check the symbols),(p<0.05). The total clearance(CI/F) of ofloxacin was 0.16+/-0.03 l/h/kg in group A, and 0.14+/-0.03 l/h/kg in group B. The half-lives of ofloxacin in two groups were similar (group A 5.3+/-0.8 hours, group B 5.7+/-0.9 hours). In addition, the other PK parameters in two groups were also similar.CONCLUSIONS:
The pharmacokinetics of ofloxacin in patients with MDR-Tb appears to be comparable with those of normal subjects, and the extent of emaciation appears to have an influence on the pharmacokinetics of ofloxacin in chronic debilitated MDR-Tb patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aminosalicylic Acid
/
Prothionamide
/
Pharmacokinetics
/
Kanamycin
/
Streptomycin
/
Ofloxacin
/
Chromatography, High Pressure Liquid
/
Tuberculosis, Multidrug-Resistant
/
Area Under Curve
/
Cycloserine
Type of study:
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Tuberculosis and Respiratory Diseases
Year:
2002
Type:
Article
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