Quantitative Computed Tomography of Pulmonary Emphysema and Ventricular Function in Chronic Obstructive Pulmonary Disease Patients with Pulmonary Hypertension
Korean Journal of Radiology
;
: 871-877, 2014.
Article
in English
| WPRIM
| ID: wpr-228616
ABSTRACT
OBJECTIVE:
This study strived to evaluate the relationship between degree of pulmonary emphysema and cardiac ventricular function in chronic obstructive pulmonary disease (COPD) patients with pulmonary hypertension (PH) using electrocardiographic-gated multidetector computed tomography (CT). MATERIALS ANDMETHODS:
Lung transplantation candidates with the diagnosis of COPD and PH were chosen for the study population, and a total of 15 patients were included. The extent of emphysema is defined as the percentage of voxels below -910 Hounsfield units in the lung windows in whole lung CT without intravenous contrast. Heart function parameters were measured by electrocardiographic-gated CT angiography. Linear regression analysis was conducted to examine the associations between percent emphysema and heart function indicators.RESULTS:
Significant correlations were found between percent emphysema and right ventricular (RV) measurements, including RV end-diastolic volume (R2 = 0.340, p = 0.023), RV stroke volume (R2 = 0.406, p = 0.011), and RV cardiac output (R2 = 0.382, p = 0.014); the correlations between percent emphysema and left ventricular function indicators were not observed.CONCLUSION:
The study revealed that percent emphysema is correlated with RV dysfunction among COPD patients with PH. Based on our findings, percent emphysema can be considered for use as an indicator to predict the severity of right ventricular dysfunction among COPD patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pulmonary Emphysema
/
Regression Analysis
/
Ventricular Function
/
Pulmonary Disease, Chronic Obstructive
/
Electrocardiography
/
Multidetector Computed Tomography
/
Heart Ventricles
/
Hypertension, Pulmonary
/
Lung
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Korean Journal of Radiology
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS