Nuclear Medicine Methods of Rejection Diagnosis in Transplanted Rat Model / 대한흉부외과학회지
The Korean Journal of Thoracic and Cardiovascular Surgery
;
: 379-383, 2003.
Article
in Korean
| WPRIM
| ID: wpr-228661
ABSTRACT
BACKGROUND:
An accurate diagnosis of the severity of the rejection after a heart transplantation relies on endomyocardial biopsy, but because of its invasiveness and the need for repeated examination makes it is an inappropriate monitoring method. Therefore, we have tried to find a monitoring method that is continuous and less invasive. MATERIAL ANDMETHOD:
Heterotopic heart transplantation using Ono-Lindsey Method was done in 20 rats, and then 99mTc-Pyrophosphate (PYP) scan was done after a month. Uptake ratio of transplanted heart to vertebrae (H/V) was obtained to be compared with the biopsy result.RESULT:
Rejection was defined when the H/V uptake ratio was higher than 0.09, and we compared the uptake ratio with the results of biopsy. The result was true positives was 3, true negatives 12, false negatives 2, andfalse positives 3. Therefore sensitivity was 60% and specificity was 80%, diagnostic value was 75%.CONCLUSION:
99mTc-Pyrophosphate (PYP) scan was a useful method for the evaluation of the heart transplantation rejection and it will be helpful for monitoring rejection as an non-invasive and simple method.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spine
/
Biopsy
/
Radionuclide Imaging
/
Sensitivity and Specificity
/
Heart Transplantation
/
Technetium Tc 99m Pyrophosphate
/
Models, Animal
/
Diagnosis
/
Graft Rejection
/
Heart
Type of study:
Diagnostic study
Limits:
Animals
Language:
Korean
Journal:
The Korean Journal of Thoracic and Cardiovascular Surgery
Year:
2003
Type:
Article
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