Prominent IL-12 Production and Tumor Reduction in Athymic Nude Mice after Toxoplasma gondii Lysate Antigen Treatment
The Korean Journal of Parasitology
;
: 605-612, 2014.
Article
in English
| WPRIM
| ID: wpr-229077
ABSTRACT
Toxoplasma gondii is an intracellular protozoan parasite that causes a Th1 cellular immunity. Our previous study showed that T. gondii lysate antigen (TLA) treatment in S180 tumor-bearing mice resulted in tumor reduction by suppressing CD31 expression, a marker of angiogenesis. In the present study, to investigate tumor suppressive effect of TLA under the absence of T lymphocytes, athymic nude mice were compared with euthymic mice in the anti-tumorigenic effect triggered by TLA in CT26 tumors. According to the results, intratumorally injected TLA reduced tumor growth and TIMP-1 level, a metastatic marker, in both euthymic and athymic mice. TLA treatment led to a sharp increase in IL-12 expression in serum cytokine profiling of athymic mice, and increased MyD88 signals in macrophages derived from the bone marrow, implying the activation of innate immunity. The selective induction of IL-12 by TLA treatment had an anti-tumorigenic effect.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Toxoplasma
/
Treatment Outcome
/
Interleukin-12
/
Disease Models, Animal
/
Myeloid Differentiation Factor 88
/
Immunity, Innate
/
Immunotherapy
/
Macrophages
/
Mice, Inbred BALB C
/
Mice, Nude
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
The Korean Journal of Parasitology
Year:
2014
Type:
Article
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