Sterile Inflammation after Intravitreal Injection of Aflibercept in a Korean Population
Korean Journal of Ophthalmology
;
: 325-330, 2015.
Article
in English
| WPRIM
| ID: wpr-229268
ABSTRACT
PURPOSE:
To report the frequency and clinical features of sterile inflammation after intravitreal aflibercept injection in a Korean population.METHODS:
A single-center, retrospective study was performed in patients who received intravitreal aflibercept from July 2013 through January 2015.RESULTS:
A total of four cases of post-injection sterile inflammation were identified from 723 aflibercept injections in 233 patients. Patients presented 1 to 13 days after intravitreal aflibercept injection (mean, 5 days). The mean baseline visual acuity was 20 / 60, which decreased to 20 / 112 at diagnosis but ultimately recovered to 20 / 60. Three cases had inflammatory cells in the anterior chamber (mean, 2.25+; range, 0 to 4+), and all cases had vitritis (mean, 3+; range, 2+ to 4+). No patients had pain. Only one patient underwent anterior chamber sampling (culture negative) and injection of antibiotics. Three of four patients were treated with a topical steroid, and all experienced improvement in their symptoms and signs of inflammation.CONCLUSIONS:
The overall incidence of sterile inflammation after intravitreal aflibercept injection in a Korean population was 4 of 723 injections (0.55%), or 4 of 233 patients (1.79%). Sterile inflammation after intravitreal aflibercept injection typically presents without pain, and the visual outcomes are generally favorable.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recombinant Fusion Proteins
/
Visual Acuity
/
Macular Edema
/
Incidence
/
Retrospective Studies
/
Follow-Up Studies
/
Treatment Outcome
/
Receptors, Vascular Endothelial Growth Factor
/
Vascular Endothelial Growth Factor A
/
Republic of Korea
Type of study:
Incidence study
/
Observational study
/
Prognostic study
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Korean Journal of Ophthalmology
Year:
2015
Type:
Article
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