Factors Affecting Treatment Outcome of Graft Infection Following Penetrating Keratoplasty
Korean Journal of Ophthalmology
;
: 301-308, 2015.
Article
in English
| WPRIM
| ID: wpr-229271
ABSTRACT
PURPOSE:
To evaluate the factors affecting treatment outcome of graft infection following penetrating keratoplasty (PKP).METHODS:
In this retrospective study, 28 patients who underwent PKP between January 2005 and January 2013 and who were diagnosed with graft infection were classified into a treatment success group or a treatment failure group. Demographic and clinical characteristics, as well as the results of the microbiologic investigation, were analyzed and compared. A subsequent binary logistic regression analysis was performed to identify the prognostic factors affecting treatment outcome.RESULTS:
Graft infection occurred at a mean of 38.29 +/- 36.16 months (range, 1 to 96 months) after PKP. Seventeen patients developed bacterial keratitis, and 11 patients developed fungal keratitis. Overall, of the 28 patients, nine (32.1%) were classified in the treatment failure group. Multivariate analysis identified pre-existing graft failure (p = 0.019), interval longer than 72 hours between donor death and PKP (p = 0.010), and fungal infection (p = 0.026) as significant risk factors for treatment failure.CONCLUSIONS:
Pre-existing graft failure, extended interval between donor death and PKP, and fungal infection were important risk factors for treatment failure of graft infection following PKP.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Surgical Wound Infection
/
Eye Infections, Bacterial
/
Eye Infections, Fungal
/
Retrospective Studies
/
Risk Factors
/
Keratoplasty, Penetrating
/
Treatment Outcome
/
Graft Survival
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
English
Journal:
Korean Journal of Ophthalmology
Year:
2015
Type:
Article
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