Localized 1H-MR Spectroscopy in Moyamoya Disease before and after Revascularization Surgery
Korean Journal of Radiology
;
: 71-78, 2003.
Article
in English
| WPRIM
| ID: wpr-229500
ABSTRACT
OBJECTIVE:
To evaluate, using localized proton magnetic resonance spectroscopy (1H-MRS), the cerebral metabolic change apparent after revascularization surgery in patients with moyamoya disease. MATERIALS ANDMETHODS:
Sixteen children with moyamoya disease and eight age-matched normal controls underwent MR imaging, MR angiography, conventional angiography, and 99mTc- ECD SPECT. Frontal white matter and the basal ganglia of both hemispheres were subjected to localized 1H-MRS, and after revascularization surgery, four patients underwent follow-up 1H-MRS.RESULTS:
Decreased NAA/Cr ratios (1.35+/-0.14 in patients vs. 1.55+/-0.24 in controls) and Cho/Cr ratios (0.96+/-0.13 in patients vs. 1.10+/-0.11 in controls) were observed in frontal white matter. After revascularization surgery, NAA/Cr and Cho/Cr ratios in this region increased. In the basal ganglia, there is no abnormal metabolic ratios.CONCLUSION:
Localized 1H-MRS revealed abnormal metabolic change in both hemispheres of children with moyamoya disease. Because of its non-invasive nature, 1H-MRS is potentially useful for the preoperative evaluation of metabolic abnormalities and their postoperative monitoring.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
English
Journal:
Korean Journal of Radiology
Year:
2003
Type:
Article
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